Article
Multidimensional epistasis and the disadvantage of sex.
Proceedings of the National Academy of Sciences of the United States of America - 9 Oct 2001
Kondrashov F A, Kondrashov A S
Abstract excerpt
Sex is thought to facilitate accumulation of initially rare beneficial mutations by allowing simultaneous allele replacements at many loci. However, this advantage of sex depends on a restrictive assumption that the fitness of a genotype is determined by fitness potential, a single intermediate variable to which all loci contribute additively, so that new alleles can accumulate in any order. Individual-based...
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