Article
SCA8 repeat expansions in ataxia: a controversial association.
Neurology - 9 Oct 2001
Sobrido M J, Cholfin J A, Perlman S, Pulst S M, Geschwind D H
Abstract excerpt
The observation of large SCA8 alleles in healthy control subjects and nonataxic patients, together with a lack of segregation of the expanded repeat with ataxia in several families, has raised questions about the pathogenic role of the SCA8 expansion. The authors found allele sizes within the proposed pathogenic range in three patients with ataxia of unknown etiology, in two individuals from pedigrees with either...
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