Effects of the ecdysoneless mutant on synaptic efficacy and structure at the neuromuscular junction in Drosophila larvae during normal and prolonged development.

Abstract excerpt

Hormonal regulation in development and maintenance of synaptic transmission involves examination of both the presynaptic and postsynaptic components and a system in which the hormones can be controlled. We used the ecdysoneless heat-sensitive mutation (l(3)ecd(1)/l(3)ecd(1)) of Drosophila to provide the ability to regulate endogenous ecdysone production at various larval stages. In conjunction, we used the...

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