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Article

Glycosidase active site mutations in human alpha-L-iduronidase.

Glycobiology - 1 Sept 2001

Brooks D A, Fabrega S, Hein L K, Parkinson E J, Durand P, Yogalingam G, Matte U, Giugliani R, Dasvarma A, Eslahpazire J, Henrissat B, Mornon J P, Hopwood J J, Lehn P

Abstract excerpt

Mucopolysaccharidosis type I (MPS I; McKusick 25280) results from a deficiency in alpha-L-iduronidase activity. Using a bioinformatics approach, we have previously predicted the putative acid/base catalyst and nucleophile residues in the active site of this human lysosomal glycosidase to be Glu182 and Glu299, respectively. To obtain experimental evidence supporting these predictions, wild-type alpha-L-iduronidase...

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PMID: 11555618
DOI: 10.1093/glycob/11.9.741

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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