Immunogene therapy of tumors with vaccine based on <i>Xenopus</i> homologous vascular endothelial growth factor as a model antigen

Abstract excerpt

Overcoming immune tolerance of the growth factors associated with tumor growth should be a useful approach to cancer therapy by active immunity. We used vascular endothelial growth factor (VEGF) as a model antigen to explore the feasibility of the immunogene tumor therapy with a vaccine based on a single xenogeneic homologous gene, targeting the growth factors associated with angiogenesis. To test this concept,...

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