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Article

Recombination in the hemagglutinin gene of the 1918 "Spanish flu".

Science (New York, N.Y.) - 7 Sept 2001

Gibbs M J, Armstrong J S, Gibbs A J

Abstract excerpt

When gene sequences from the influenza virus that caused the 1918 pandemic were first compared with those of related viruses, they yielded few clues about its origins and virulence. Our reanalysis indicates that the hemagglutinin gene, a key virulence determinant, originated by recombination. The "globular domain" of the 1918 hemagglutinin protein was encoded by a part of a gene derived from a swine-lineage...

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Share to Hemagglutinin Glycoproteins, Influenza Virus
Share to Influenza A virus
Share to Influenza, Human

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Monte Carlo Method

Share to Protein Structure, Tertiary

Share to Recombination, Genetic

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Source

Identifiers

PMID: 11546876
DOI: 10.1126/science.1061662

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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