Article
Repair of DNA double-strand breaks and cell killing by charged particles.
Advances in space research : the official journal of the Committee on Space Research (COSPAR) - 1 Jan 1998
Eguchi-Kasai K, Murakami M, Itsukaichi H, Fukutsu K, Yatagai F, Kanai T, Ohara H, Sato K
Abstract excerpt
It has been suggested that it is not simple double-strand breaks (dsb) but the non-reparable breaks which correlate well with the high biological effectiveness of high LET radiations for cell killing (Kelland et al., 1988; Radford, 1986). We have compared the effects of charged particles on cell death in 3 pairs of cell lines which are normal or defective in the repair of DNA dsbs. For the cell lines SL3-147,...
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