Article
The structure of the lipooligosaccharide (LOS) from the alpha-1,2-N-acetyl glucosamine transferase (rfaK(NMB)) mutant strain CMK1 of Neisseria meningitidis: implications for LOS inner core assembly and LOS-based vaccines.
Glycobiology - 1 Aug 2001
Rahman M M, Kahler C M, Stephens D S, Carlson R W
Abstract excerpt
The inner core structures of the lipooligosaccharides (LOS) of Neisseria meningitidis are potential vaccine candidates because both bactericidal and opsonic antibodies can be generated against these epitopes. In an effort to better understand LOS biosynthesis and the potential immunogenicity of t...
Topics
- Bacterial Proteins
- Carbohydrate Sequence
- Lipopolysaccharides
- Meningococcal Vaccines
- Molecular Sequence Data
- Mutation
- N-Acetylglucosaminyltransferases
- Neisseria meningitidis
- Nuclear Magnetic Resonance, Biomolecular