Article
Woc (without children) gene control of ecdysone biosynthesis in Drosophila melanogaster.
Molecular and cellular endocrinology - 5 Jul 2001
Warren J T, Wismar J, Subrahmanyam B, Gilbert L I
Abstract excerpt
The first step in ecdysteroidogenesis, i.e. the 7,8-dehydrogenation of dietary cholesterol (C) to 7-dehydrocholesterol (7dC), is blocked in Drosophila melanogaster homozygous woc (without children) third instar larval ring glands (source of ecdysone). Unlike ring glands from wild-type D. melanogaster larvae, glands from woc mutants cannot convert radiolabelled C or 25-hydroxycholesterol (25C) to 7dC or...
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