Article
Association between erythromycin resistance and ability to enter human respiratory cells in group A streptococci.
Lancet (London, England) - 7 Jul 2001
Facinelli B, Spinaci C, Magi G, Giovanetti E, E Varaldo P
Abstract excerpt
BACKGROUND: An increase in erythromycin resistance rates among group A streptococci has been reported in some European countries. These bacteria, long thought to be extracellular pathogens, can be efficiently internalised by, and survive within, human cells of respiratory-tract origin. Macrolide antibiotics enter eukaryotic cells, whereas beta-lactams are essentially confined to the extracellular fluid. A protein...
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