Article
Survey of human mitochondrial diseases using new genomic/proteomic tools.
Genome biology - 1 Jan 2001
Plasterer T N, Smith T F, Mohr S C
Abstract excerpt
BACKGROUND: We have constructed Bayesian prior-based, amino-acid sequence profiles for the complete yeast mitochondrial proteome and used them to develop methods for identifying and characterizing the context of protein mutations that give rise to human mitochondrial diseases. (Bayesian priors are conditional probabilities that allow the estimation of the likelihood of an event - such as an amino-acid...
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