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Matrix metalloproteinases and tissue inhibitors of metalloproteinases in human fetal testis and ovary

1 Jul 2001

Abstract excerpt

Matrix metalloproteinases (MMP) and tissue inhibitors of metalloproteinases (TIMP) are major regulators of tissue remodelling of the extracellular matrix (ECM) and may also be involved in the control of growth factor availability. We have investigated their production and localization in the developing human gonad during mid-gestation using zymographic techniques and immunohistochemistry. The secretion of MMP-2,...

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PMID: 11420387
DOI: 10.1093/molehr/7.7.641

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