Mutation and recombination with tight linkage.

Abstract excerpt

An exact solution of the mutation-recombination equation in continuous time is presented, with linear ordering of the sites and at most one mutation or crossover event taking place at every instant of time. The differential equation may be obtained from a mutation-recombination model with discrete generations, in the limit of short generations, or weak mutation and recombination. The solution relies on the...

Topics

• Evolution, Molecular
• Linkage Disequilibrium
• Models, Genetic
• Mutation
• Recombination, Genetic