Article
CML66, a broadly immunogenic tumor antigen, elicits a humoral immune response associated with remission of chronic myelogenous leukemia.
Proceedings of the National Academy of Sciences of the United States of America - 19 Jun 2001
Yang X F, Wu C J, McLaughlin S, Chillemi A, Wang K S, Canning C, Alyea E P, Kantoff P, Soiffer R J, Dranoff G, Ritz J
Abstract excerpt
This report describes a tumor-associated antigen, termed CML66, initially cloned from a chronic myelogenous leukemia (CML) cDNA expression library. CML66 encodes a 583-aa protein with a molecular mass of 66 kDa and no significant homology to other known genes. CML66 gene is localized to human chromosome 8q23, but the function of this gene is unknown. CML66 is expressed in leukemias and a variety of solid tumor...
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