Absence of Mutations in the Coding Regions of Follicle-Stimulating Hormone Receptor Gene in Singapore Chinese Women with Premature Ovarian Failure and Polycystic Ovary Syndrome

Abstract excerpt

Normal gonadal function is critically dependent on the integrity of pituitary-gonadal axis, where follicle-stimulating hormone (FSH) plays a key role. In the female, FSH is required for follicular growth, estrogen production and oocyte maturation. Its function is mediated by its specific receptor (FSHR), and defective FSHR has been shown to affect folliculogenesis and ovarian function. In this study, we screened...

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