Article
Mutational analysis of the BMP-1 gene in patients with gastroschisis.
Journal of pediatric surgery - 1 Jun 2001
Komuro H, Mori M, Hayashi Y, Fukagawa M, Makino S, Takahara K, Greenspan D S, Momoi M Y
Abstract excerpt
BACKGROUND: Gastroschisis is a rare abdominal wall defect. Although the pathogenesis of gastroschisis is unknown, there is some evidence of the genetic etiology of gastroschisis. Recently, a functionally null deletion of the mouse bone morphogenic protein-1 (BMP-1) gene resulted in a phenotype that resembled a human neonate with gastroschisis. BMP-1 thus became the first potential candidate gene for...
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