Article
Molecular defects underlying the Kell null phenotype.
The Journal of biological chemistry - 20 Jul 2001
Lee S, Russo D C, Reiner A P, Lee J H, Sy M Y, Telen M J, Judd W J, Simon P, Rodrigues M J, Chabert T, Poole J, Jovanovic-Srzentic S, Levene C, Yahalom V, Redman C M
Abstract excerpt
Expression of the Kell blood group system is dependent on two proteins, Kell and XK, that are linked by a single disulfide bond. Kell, a type II membrane glycoprotein, is a zinc endopeptidase, while XK, which has 10 transmembrane domains, is a putative membrane transporter. A rare phenotype termed Kell null (Ko) is characterized by the absence of Kell protein and Kell antigens from the red cell membrane and...
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