Article
Increased reproductive success of MHC class II heterozygous males among free-ranging rhesus macaques.
Human genetics - 1 Mar 2001
Sauermann U, Nürnberg P, Bercovitch F B, Berard J D, Trefilov A, Widdig A, Kessler M, Schmidtke J, Krawczak M
Abstract excerpt
Gene conversion and balancing selection have been invoked to explain the ubiquitous diversity of the antigen-presenting proteins encoded in the vertebrate major histocompatibility complex (MHC). In the present study, direct evidence for over-dominant selection promoting MHC diversity in primates is provided by the observation that, in a large free-ranging population of rhesus macaques, males heterozygous at MHC...
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