Article
Amyloid goiter as the initial manifestation of systemic amyloidosis due to familial mediterranean fever with homozygous MEFV mutation.
Thyroid : official journal of the American Thyroid Association - 1 Apr 2001
Sbai A, Wechsler B, Leenhardt L, Beaufils H, Hoang C, Ménégaux F, Piette J C
Abstract excerpt
We describe a case of amyloid goiter revealing a systemic amyloidosis secondary to familial Mediterranean fever (FMF) with homozygous MEFV mutation, and we review the literature. A 45-year-old euthyroid Sephardic man, known to suffer from FMF, developed a goiter with cold nodule, after which a subtotal thyroidectomy was performed. Histologic evaluation revealed diffuse AA amyloid deposition without any associated...
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