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Article

Sensitivity and specificity of denaturing high-pressure liquid chromatography for unknown protein C gene mutations.

Genetic testing - 1 Jan 2001

Taliani M R, Roberts S C, Dukek B A, Pruthi R K, Nichols W L, Heit J A

Abstract excerpt

Screening methods for unknown DNA sequence variations are laborious, expensive, and relatively insensitive. To evaluate the sensitivity and specificity of denaturing high-pressure liquid chromatography (DHPLC) screening for unknown protein C gene (PROC) mutations, we studied 31 PROC-deficient patients. Eleven amplimers containing 4 kb of the PROC gene and spanning all exons, splice junctions, and the putative...

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PMID: 11336399
DOI: 10.1089/109065701750168680

Genes

PROC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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