Article
TP53 deleted cells in de novo glioblastomas using fluorescence in situ hybridization.
Pathology international - 1 Mar 2001
Horiguchi H, Sano T, Hirose T
Abstract excerpt
Glioblastoma (GBM) has been known to have two distinct genetic pathways of tumorigenesis. Secondary GBM shows frequent TP53 mutation, but de novo (primary) GBM is usually independent of TP53 alteration. However, the subpopulation of TP53 altered cells in the latter tumor is obscure. In order to assess TP53 deleted cells in de novo GBM quantitatively, we performed dual color fluorescence in situ hybridization...
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