Article
Genetic control of bone density and turnover: role of the collagen 1alpha1, estrogen receptor, and vitamin D receptor genes.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Apr 2001
Brown M A, Haughton M A, Grant S F, Gunnell A S, Henderson N K, Eisman J A
Abstract excerpt
Genetic factors are known to influence both the peak bone mass and probably the rate of change in bone density. A range of regulatory and structural genes has been proposed to be involved including collagen 1alpha (COL1A1), the estrogen receptor (ER), and the vitamin D receptor (VDR), but the actual genes involved are uncertain. We therefore studied the role of the COL1A1 and VDR loci in control of bone density...
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