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Article

Trehalose accumulation during cellular stress protects cells and cellular proteins from damage by oxygen radicals.

The Journal of biological chemistry - 29 Jun 2001

Benaroudj N, Lee D H, Goldberg A L

Abstract excerpt

The disaccharide trehalose, which accumulates dramatically during heat shock and stationary phase in many organisms, enhances thermotolerance and reduces aggregation of denatured proteins. Here we report a new role for trehalose in protecting cells against oxygen radicals. Exposure of Saccharomyces cerevisiae to a mild heat shock (38 degrees C) or to a proteasome inhibitor (MG132) induced trehalose accumulation...

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Identifiers

PMID: 11301331
DOI: 10.1074/jbc.M101487200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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