Article
Epstein--Barr virus gene polymorphisms in Chinese Hodgkin's disease cases and healthy donors: identification of three distinct virus variants.
The Journal of general virology - 1 May 2001
Zhou X-G, Sandvej K, Li P-J, Ji X-L, Yan Q-H, Zhang X-P, Da J-P, Hamilton-Dutoit S J
Abstract excerpt
Epstein--Barr virus (EBV) is associated with several malignancies. Specific EBV gene variants, e.g. the BamHI f configuration, a C-terminal region 30 bp deletion in the latent membrane protein-1 (LMP1) gene (del-LMP) and the loss of an XhoI site in LMP1 (XhoI-loss), are found in Chinese cases of nasopharyngeal carcinoma (NPC), suggesting that EBV sequence variation may be involved in oncogenesis. In order to...
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