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Article

Molecular basis of partial lipodystrophy and prospects for therapy.

Trends in molecular medicine - 1 Mar 2001

Hegele R A

Abstract excerpt

Lipodystrophy is characterized by altered partition of adipose tissue. Despite heterogeneous causes, which include genetic, autoimmune and drug-induced forms, lipodystrophy syndromes have similar metabolic attributes, including insulin resistance, hyperlipidemia and diabetes. The mechanisms underlying the insulin resistance are unknown. One form of lipodystrophy, namely Dunnigan-type familial partial...

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Topics

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 11286783
DOI: 10.1016/s1471-4914(01)01930-x

Genes

LMNA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Molecular basis of partial lipodystrophy and prospects for therapy.PMID 11286783Read ↗

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Navigating Lipodystrophy: Insights from Laminopathies and Beyond.Semantic proximity Read ↗

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The molecular basis of genetic lipodystrophies.Semantic proximity Read ↗

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The R439C mutation in LMNA causes lamin oligomerization and susceptibility to oxidative stress.Semantic proximity Read ↗

A-type lamin-linked lipodystrophies.Semantic proximity Read ↗

The Clinical Characteristics and Potential Molecular Mechanism of LMNA Mutation-Related Lipodystrophy.Semantic proximity Read ↗

[Familial partial lipodystrophy (Dunnigan syndrome) due to LMNA gene mutation: The first description of its clinical case in Russia].Semantic proximity Read ↗

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