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Article

Resistance to Lyme disease in decorin-deficient mice

1 Apr 2001

Abstract excerpt

Microbial adhesion to the host tissue represents an early, critical step in the pathogenesis of most infectious diseases. BORRELIA: burgdorferi, the causative agent of Lyme disease (LD), expresses two surface-exposed decorin-binding adhesins, DbpA and DbpB. A decorin-deficient (Dcn(-/-)) mouse was recently developed and found to have a relatively mild phenotype. We have now examined the process of experimental LD...

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PMID: 11285303
DOI: 10.1172/jci11692

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