[Growth of Escherichia coli cell culture and frequency of mutation, induced by N-methyl-N'-nitro-N-nitrosoguanidine].

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Article

[Growth of Escherichia coli cell culture and frequency of mutation, induced by N-methyl-N'-nitro-N-nitrosoguanidine].

Mikrobiologiia - 1 Jan 2000

Goliasnaia N V, Tiurina N A

Abstract excerpt

The rate of Escherichia coli mutation with N-methyl-N'-nitro-N-nitrosoguanidine was found to depend on the age of the culture and the pH value of the incubation medium. The mutability of late-logarithmic cells was higher than that of mid-logarithmic cells. Rifampicin, a transcription inhibitor, enhanced the mutagenic action of MNNG on cells from the late logarithmic and early stationary phases suspended in a...

Topics

Culture Media
Escherichia coli
Hydrogen-Ion Concentration
Methylnitronitrosoguanidine
Mutagens
Mutation
Rifampin

Source

Open in PubMed

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PMID: 11195581

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