Article
[Influence of FH Valencia 1 and 2 mutations of the LDL receptor gene on the response to simvastatin in subjects with molecularly defined heterozygous familial hypercholesterolemia in Spain].
Medicina clinica - 27 Jan 2001
Real J T, Chaves F J, Civera M, García-García A B, Ascaso J F, Armengod M E, Carmena R
Abstract excerpt
BACKGROUND: To analyse whether the molecular diagnosis in FH patients is useful to predict the response to treatment with simvastatin in a south European population. SUBJECTS AND METHOD: A randomised clinical trial with no control group, with 20 mg/day of simvastatin was conducted in 27 genetically diagnosed FH subjects (11 male) from 8 FH families, randomly selected from 30 FH families with a molecular...
Topics
- Adult
- Anticholesteremic Agents
- Apolipoproteins
- Female
- Humans
- Hyperlipoproteinemia Type II
- Lipoproteins
- Male
- Middle Aged
- Mutation
- Receptors, LDL
- Simvastatin
- Spain