Article
A nonsense mutation in the alpha1 subunit of the inhibitory glycine receptor associated with bovine myoclonus.
Molecular and cellular neurosciences - 1 Feb 2001
Pierce K D, Handford C A, Morris R, Vafa B, Dennis J A, Healy P J, Schofield P R
Abstract excerpt
Inherited congenital myoclonus of Poll Hereford calves is an autosomal recessive disease characterized by hyperesthesia and myoclonic jerks of the skeletal musculature that occur both spontaneously and in response to sensory stimuli. Binding studies have previously shown that myoclonus is associated with specific loss of [(3)H]strychnine-binding sites from spinal cord and brain stem in affected calves. In order...
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