NF-κB: pivotal mediator or innocent bystander in atherogenesis?

Abstract excerpt

Atherosclerosis and its clinical manifestations of heart attack, stroke, and peripheral vascular insufficiency are a major cause of morbidity and mortality among both men and women. Multiple risk factors including hypertension, diabetes mellitus, smoking, and lipoprotein disorders are involved in the pathogenesis of this chronic inflammatory disease of arteries. The development of early atherosclerotic lesions...

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