HLA-B*0811: another example of a single point substitution of the HLA-B*0801 allele.

Abstract excerpt

The described alle HLA-B*0811 is of Caucasoid origin. Most likely it derived from a point mutation of the B*0801 allele at position 559, where an adenine was converted to guanine. This position corresponds to codon 163 and resulted in an amino acid change from threonine to alanine. This substitution may influence both, T-cell interactions and/or peptide binding.

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