Article
Protection of<i>Aotus</i>Monkeys by<i>Plasmodium falciparum</i>EBA‐175 Region II DNA Prime–Protein Boost Immunization Regimen
15 Jan 2001
Abstract excerpt
Aotus monkeys received 4 doses of Plasmodium falciparum EBA-175 region II vaccine as plasmid DNA (Dv-Dv) or recombinant protein in adjuvant (Pv-Pv) or as 3 doses of DNA and 1 dose of protein (Dv-Pv). After 3 doses, antibody titers were approximately 10(4) in DNA-immunized monkeys and 10(6) in protein-immunized monkeys. A fourth dose did not significantly boost antibody responses in the Dv-Dv only or Pv-Pv only...
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