Article
Novel DNA binding domain and genetic regulation model of Bacillus subtilis transition state regulator abrB.
Nature structural biology - 1 Dec 2000
Vaughn J L, Feher V, Naylor S, Strauch M A, Cavanagh J
Abstract excerpt
We have determined the high resolution NMR solution structure of the novel DNA binding domain of the Bacillus subtilis transition state regulator AbrB. Comparisons of the AbrB DNA binding domain with DNA binding proteins of known structure show that it is a member of a completely novel class of DNA recognition folds that employs a dimeric topology for cellular function. This new DNA binding conformation is...
Topics
- Bacillus subtilis
- Bacterial Proteins
- Chromatography, Gel
- Chromatography, High Pressure Liquid
- DNA
- DNA-Binding Proteins
- Dimerization
- Gene Expression Regulation, Bacterial
- Mass Spectrometry
- Models, Genetic
- Models, Molecular
- Mutation
- Nuclear Magnetic Resonance, Biomolecular