Article
Phase I study in advanced cancer patients of a diversified prime-and-boost vaccination protocol using recombinant vaccinia virus and recombinant nonreplicating avipox virus to elicit anti-carcinoembryonic antigen immune responses.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 1 Dec 2000
Marshall J L, Hoyer R J, Toomey M A, Faraguna K, Chang P, Richmond E, Pedicano J E, Gehan E, Peck R A, Arlen P, Tsang K Y, Schlom J
Abstract excerpt
PURPOSE: This trial sought to determine, for the first time, the validity in human vaccinations of using two different recombinant vaccines in diversified prime-and-boost regimens to enhance T-cell responses to a tumor antigen. PATIENTS AND METHODS: Eighteen patients with advanced tumors expressi...
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