Article
DNA damage after chemotherapy correlates with tumor response and survival in small cell lung cancer patients.
Mutation research - 30 Nov 2000
Silva J M, Garcia J M, Dominguez G, Silva J, Rodriguez R, Portero J L, Corbacho C, Provencio M, España P, Bonilla F
Abstract excerpt
To explore the induction of chemotherapy (CT) DNA damage and its correlation with tumor response and patient survival, we undertook the present study in 20 small cell lung cancer (SCLC) patients. All patients underwent the same treatment based on CT courses of carboplatin and etoposide. Blood samples were taken before and immediately after CT and every 12 weeks during follow-up. Nuclear DNA damage was determined...
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