Article
A Japanese patient with frontotemporal dementia and parkinsonism by a tau P301S mutation.
Neurology - 24 Oct 2000
Yasuda M, Yokoyama K, Nakayasu T, Nishimura Y, Matsui M, Yokoyama T, Miyoshi K, Tanaka C
Abstract excerpt
The authors report a patient carrying a missense mutation in exon 10 of tau that causes a substitution at codon 301 (P301S). Although the patient shares the rapidly progressive frontotemporal dementia of the other reported pedigrees with P301S, the clinical phenotype is unique in that parkinsonism was a major symptom in the early stage and because behavioral symptoms with dementia became prominent 2 years after...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.