Article
A clinical pathological comparison of three families with frontotemporal dementia and identical mutations in the tau gene (P301L)
Brain : a journal of neurology - 1 Apr 1999
Bird T D, Nochlin D, Poorkaj P, Cherrier M, Kaye J, Payami H, Peskind E, Lampe T H, Nemens E, Boyer P J, Schellenberg G D
Abstract excerpt
We investigated three separate families (designated D, F and G) with frontotemporal dementia that have the same molecular mutation in exon 10 of the tau gene (P301L). The families share many clinical characteristics, including behavioural aberrations, defective executive functions, language deficits, relatively preserved constructional abilities and frontotemporal atrophy on imaging studies. However, Family D has...
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