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Article

Human PRRX1 and PRRX2 genes: cloning, expression, genomic localization, and exclusion as disease genes for Nager syndrome.

Mammalian genome : official journal of the International Mammalian Genome Society - 1 Nov 2000

Norris R A, Scott K K, Moore C S, Stetten G, Brown C R, Jabs E W, Wulfsberg E A, Yu J, Kern M J

Abstract excerpt

In this study, we extend our examination of the function of the Prrx1 (a.k.a Mhox, Prx1, K-2, and Pmx1) as well as Prrx2 (a.k.a. S8 and Prx2) genes by characterizing the expression of the human orthologs and their potential for causing specific human malformations. The expression pattern of PRRX2 and its close relative, PRRX1, were analyzed in human tissue by RT-PCR. Although the expression of these human genes...

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Share to Abnormalities, Multiple
Share to Chromosomes, Human, Pair 9

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cloning, Molecular

Share to Gene Expression Regulation, Developmental

Share to Homeodomain Proteins

Share to Mandibulofacial Dysostosis

Share to Sequence Homology, Amino Acid

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Source

Identifiers

PMID: 11063257
DOI: 10.1007/s003350010193

Genes

PRRX1
PRRX2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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