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Zidovudine triphosphate and lamivudine triphosphate concentration–response relationships in HIV-infected persons

1 Sept 2000

Abstract excerpt

OBJECTIVE: To quantitate intracellular concentrations of zidovudine and lamivudine triphosphate and explore relationships with virologic and immunologic responses to antiretroviral therapy. DESIGN: Eight antiretroviral-naive, HIV-infected persons with CD4 T cell counts > 100 x 10(6) cells/l, and HIV RNA in plasma > 5000 copies/ml participating in a prospective, randomized, open-label study of standard dose versus...

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PMID: 11061655
DOI: 10.1097/00002030-200009290-00010

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