Article
Successful orthotopic liver transplantation for lamivudine-associated YMDD mutant hepatitis B virus.
Gastroenterology - 1 Nov 2000
Saab S, Kim M, Wright T L, Han S H, Martin P, Busuttil R W
Abstract excerpt
YMDD hepatitis B virus (HBV) mutants emerge in more than one third of patients treated with lamivudine. The development of escape mutants potentially limits the efficacy of this new therapy for chronic HBV infection. Transplant centers may be hesitant to perform orthotopic liver transplantation (OLT) in patients with progressive liver disease who develop the YMDD mutant because of concerns of graft reinfection....
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