Article
From genetics to mechanism of disease liability.
Advances in genetics - 1 Jan 2001
Lalouel J M
Abstract excerpt
The molecular basis of single-gene Mendelian disorders resulting from gain or loss of function is being clarified at a rapid pace. Progress in the genetics of common disease, by contrast, has been frustratingly limited, as we discuss by reference to essential hypertension (EH). The application of standard genetic paradigms to hypertension research has yielded remarkable findings. Arterial pressure (AP) variation...
Topics
- Angiotensinogen
- Animals
- Chromosome Mapping
- Genetic Predisposition to Disease
- Genetic Techniques
- Genetic Variation
- Haplotypes
- Humans
- Mice
- Rats