Article
The nonfunctional allele TCRBV6S1B is strongly associated with Helicobacter pylori infection.
Infection and immunity - 1 Nov 2000
Kunstmann E, Hardt C, Elitok E, Harder M, Suerbaum S, Peitz U, Schmiegel W, Epplen J T
Abstract excerpt
To determine genetic susceptibility factors for Helicobacter pylori infection, polymorphic T-cell receptor gene elements were investigated in 203 H. pylori-infected individuals and 180 uninfected individuals (controls). H. pylori infection is highly associated with individuals homozygous for the nonfunctional TCRBV6S1B element (odds ratio = 5.9; chi(2) = 13; P = 0.00032; P value corrected for multiple comparisons...
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