Article
Primary structure of human hepatocellular carcinoma-associated aldehyde dehydrogenase.
Biochimica et biophysica acta - 29 Sept 2000
Satomichi A, Nakajima Y, Takeuchi A, Takagaki Y, Saigenji K, Shibuya A
Abstract excerpt
Tumor-associated aldehyde dehydrogenase (T-ALDH) is strongly expressed in hepatocellular carcinoma (HCC) but undetectable in normal liver. In the present study, this enzyme from human HCC, HCC T-ALDH, was purified and the partial amino acid sequences (384 residues) determined by direct protein sequencing matched the amino acid sequence (453 residues) deduced from cloned HCC T-ALDH cDNAs with an open reading...
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