Article
Genomic organization and amplification of the human plakoglobin gene (JUP).
Experimental dermatology - 1 Oct 2000
Whittock N V, Eady R A, McGrath J A
Abstract excerpt
Plakoglobin is a globular protein common to the intracellular plaques of adhesive junctions, predominantly desmosomes and adherens junctions. Recently, a number of pathogenic mutations have been described in other components of desmosomes, specifically in plakophilin 1, desmoplakin and desmoglein 1. The phenotype of affected patients mainly involves thickening of palm and sole skin (keratoderma). Although no...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.