Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cathepsin D deficiency induces lysosomal storage with ceroid lipofuscin in mouse CNS neurons.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 15 Sept 2000

Koike M, Nakanishi H, Saftig P, Ezaki J, Isahara K, Ohsawa Y, Schulz-Schaeffer W, Watanabe T, Waguri S, Kametaka S, Shibata M, Yamamoto K, Kominami E, Peters C, von Figura K, Uchiyama Y

Abstract excerpt

Cathepsin D-deficient (CD-/-) mice have been shown to manifest seizures and become blind near the terminal stage [approximately postnatal day (P) 26]. We therefore examined the morphological, immunocytochemical, and biochemical features of CNS tissues of these mice. By electron microscopy, autophagosome/autolysosome-like bodies containing part of the cytoplasm, granular osmiophilic deposits, and fingerprint...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blindness
Share to Cathepsin B

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cathepsin D

Share to Mitochondrial Proton-Translocating ATPases

Share to Neuronal Ceroid-Lipofuscinoses

Share to Phagosomes

Share to Proton-Translocating ATPases

Share to Tripeptidyl-Peptidase 1

Source

Open in PubMed Open full text

Identifiers

PMID: 10995834
PMCID: PMC6772823

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cathepsin D deficiency induces lysosomal storage with ceroid lipofuscin in mouse CNS neurons.PMID 10995834Read ↗

Lack of Cathepsin D in the Central Nervous System Results in Microglia and Astrocyte Activation and the Accumulation of Proteinopathy-related ProteinsSemantic proximity Read ↗

Murine Cathepsin F Deficiency Causes Neuronal Lipofuscinosis and Late-Onset Neurological DiseaseSemantic proximity Read ↗

A mutation in the ovine cathepsin D gene causes a congenital lysosomal storage disease with profound neurodegeneration.Semantic proximity Read ↗

The intracellular location and function of proteins of neuronal ceroid lipofuscinoses.Semantic proximity Read ↗

KCTD7 mutations impair the trafficking of lysosomal enzymes through CLN5 accumulation to cause neuronal ceroid lipofuscinoses.Semantic proximity Read ↗

Genetic modifiers of degeneration in the cathepsin D deficient Drosophila model for neuronal ceroid lipofuscinosis.Semantic proximity Read ↗

A mouse model of classical late-infantile neuronal ceroid lipofuscinosis based on targeted disruption of the CLN2 gene results in a loss of tripeptidyl-peptidase I activity and progressive neurodegeneration.Semantic proximity Read ↗

Pathological study of mice with total deficiency of sphingolipid activator proteins (SAP knockout mice).Semantic proximity Read ↗

CLC-3 deficiency leads to phenotypes similar to human neuronal ceroid lipofuscinosis.Semantic proximity Read ↗

Impaired autophagosomes and lysosomes in neuronopathic Gaucher disease.Semantic proximity Read ↗

Phenotypic characterization of a mouse model of juvenile neuronal ceroid lipofuscinosis.Semantic proximity Read ↗

Neurons in Niemann-Pick disease type C accumulate gangliosides as well as unesterified cholesterol and undergo dendritic and axonal alterations.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.