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Neuroinvasion by Human Respiratory Coronaviruses

1 Oct 2000

Abstract excerpt

Human coronaviruses (HCoV) cause common colds but can also infect neural cell cultures. To provide definitive experimental evidence for the neurotropism and neuroinvasion of HCoV and its possible association with multiple sclerosis (MS), we have performed an extensive search and characterization of HCoV RNA in a large panel of human brain autopsy samples. Very stringent reverse transcription-PCR with two primer...

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PMID: 10982334
DOI: 10.1128/jvi.74.19.8913-8921.2000

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