Article
Relation between choice of partner and high frequency of connexin-26 deafness.
Lancet (London, England) - 5 Aug 2000
Nance W E, Liu X Z, Pandya A
Abstract excerpt
Recessive mutations at the connexin-26 gene locus are now recognised as the cause of nearly half of all cases of genetic deafness in many populations. We suggest that this high frequency is only seen in populations with a long tradition of intermarriage among deaf people. Available data are consistent with the hypothesis that such marriages might well have contributed to the high frequency of connexin-26 deafness...
Topics
- Connexin 26
- Connexins
- Deafness
- Genes, Recessive
- Genotype
- Humans
- Mutation
- Phenotype