Article
Protein A is the von Willebrand factor binding protein on Staphylococcus aureus.
Blood - 15 Sept 2000
Hartleib J, Köhler N, Dickinson R B, Chhatwal G S, Sixma J J, Hartford O M, Foster T J, Peters G, Kehrel B E, Herrmann M
Abstract excerpt
Endovascular infection is a highly critical complication of invasive Staphylococcus aureus disease. For colonization, staphylococci must first adhere to adhesive endovascular foci. Von Willebrand factor (vWF) is a large, multimeric glycoprotein mediating platelet adhesion at sites of endothelial damage. Earlier it was demonstrated that vWF binds to and promotes the surface adhesion of S. aureus, prompting this...
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