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Article

Evidence of a molecular barrier limiting susceptibility of humans, cattle and sheep to chronic wasting disease.

The EMBO journal - 1 Sept 2000

Raymond G J, Bossers A, Raymond L D, O'Rourke K I, McHolland L E, Bryant P K, Miller M W, Williams E S, Smits M, Caughey B

Abstract excerpt

Chronic wasting disease (CWD) is a transmissible spongiform encephalopathy (TSE) of deer and elk, and little is known about its transmissibility to other species. An important factor controlling interspecies TSE susceptibility is prion protein (PrP) homology between the source and recipient species/genotypes. Furthermore, the efficiency with which the protease-resistant PrP (PrP-res) of one species induces the in...

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Source

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Identifiers

PMID: 10970836
DOI: 10.1093/emboj/19.17.4425
PMCID: PMC302048

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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