Luminacins. A Family of Capillary Tube Formation Inhibitors from Streptomyces sp. II. Biological Activities.

Abstract excerpt

Twelve of the fourteen isolated components of the luminacin family were assayed for activity to inhibit capillary tube formation in vitro. Seven of them showed potent activity with IC50 values of less than 0.1 microg/ml in a rat aorta matrix culture model. Luminacin D, the strongest inhibitor, inhibited both endothelial cell proliferation and capillary tube formation. Morphological observation suggested that...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Peptidase Inhibition and Analysis
• Share to Protease and Inhibitor Mechanisms
• Share to Signaling Pathways in Disease